Men can inherit a form of heart disease from father via Y chromosome

                                            The Y chromosome determines that a baby will be a boy


Men can inherit heart disease from their father say scientists who have tracked the condition to the Y chromosome that dads pass to sons.

By studying the DNA of over 3,000 men they found a particular version of the sex chromosome increases the risk of coronary artery disease by 50%.

As many as one in five British men carry this version of Y.

And the risk it confers is in addition to other heart risk factors like cholesterol, The Lancet reports.

Experts already know that men develop heart disease a decade earlier than women, on average. By the age of 40, the lifetime risk of heart disease is one in two for men and one in three for women.

Lifestyle factors like smoking and blood pressure are important contributors. This latest work suggests the male Y chromosome can also play a role in coronary artery disease - a common form of heart disease that kills thousands each year in the UK.

Passed down

Dr Maciej Tomaszewski, from the University of Leicester, and colleagues studied 3,233 biologically unrelated British men who were already enrolled in other medical studies investigating heart disease risk.

When they carried out genetic tests on the men they found that 90% possessed one of two common versions of Y chromosome - named haplogroup I and haplogroup R1b1b2.

And the risk of coronary artery disease among the men carrying the haplogroup I version was 50% higher than in other men.

The scientists say they now need to pinpoint precisely which genes on the Y chromosome are responsible.

But they believe they already know how they exert their effect - by upsetting a man's immune system.

Dr Maciej Tomaszewski, a clinical senior lecturer at the University's Department of Cardiovascular Sciences, said: "We are very excited about these findings as they put the Y chromosome on the map of genetic susceptibility to coronary artery disease.

"Doctors usually associated the Y chromosome with maleness and fertility but this shows it is also implicated in heart disease."

He said, ultimately, the discovery could lead to new ways to treat and prevent heart disease in men, as well as a genetic test to spot those greatest risk.

In the meantime, he said men should focus on risk factors that they already have the power to modify themselves, such as getting enough exercise and eating a healthy diet to keep their blood pressure and cholesterol down.

Dr Hélène Wilson of the British Heart Foundation, which part-funded the work, said: "Coronary heart disease is the cause of heart attacks, which claim the lives of around 50,000 UK men every year.

"Lifestyle choices such as poor diet and smoking are major causes, but inherited factors carried in DNA are also part of the picture. The next step is to identify specifically which genes are responsible and how they might increase heart attack risk."

Seven Tips Guaranteed to Improve Your Dating Life!!!

                                    How to Improve Your Dating Life



1. Nurture a sincere curiosity about people.

Dating is an exercise in getting to know the other person, and for this reason it’s important that you’re able to communicate your interest. Sometimes two people are just right for each other, but they never get to realize it because both are holding back or too focused on themselves to show true interest in their mate. Do your best to shift your attention off yourself and onto your date. So do ask questions; be curious about the person sitting in front of you. Disclose a little about yourself, something that can pique and intrigue your date. Sometimes even if a date doesn’t lead to romance, the good conversation can be worth the evening’s entertainment. At least this way, if you two don’t work out you could gain a friend for life.



2. Make yourself more attractive.

Yes, you have to go there. While at first blush it seems shallow, the reality is you lessen your chances of getting a good date by going out of your house hair uncombed, dress dowdy and eyes revealing you haven’t been sleeping well. Most of the time it’s the physical that sparks interest in the opposite sex; make sure you’re taking pains to be attractive. Do yourself a favour—visit your nearest salon and buy yourself a nice dating outfit or two --- you’ll feel more confident when you know for certain you’re a sexy beast.



3. Expand your social network.

It’s a simple case of probability. The more people you know, the greater your chances of finding someone you can connect with.

So don’t be a shy wallflower. Get yourself out socializing! Sign up for conferences and workshops, join professional organizations, get yourself to the gym. Be open to dating sites if you have the courage. If you want to be strategic, you could even connect yourself to clubs where your type is likely to hang out. The internet is a feast for finding groups of people who love the same things, so do a search of local meet-ups or social events in your area of interest.



4. Date outside your type.

If you feel bored with your dating life, chances are you’re going out with the same type all the time. Monotony is the root of dissatisfaction, so dare yourself and ask someone that in the past you wouldn’t in your wildest dreams imagine dating. Our types often reveal where we’re comfortable and sometimes it takes some shaking up to get the excitement back. You’ll never know: when you open yourself to all the possibilities, you just might find the one.



5. Get mentoring on how to flirt well.

Unfortunately, not all of us were born with the flirting gene and it’s easy to get signals mixed when you’re a newbie at it. So find someone you know who’s successful at the craft or attend a workshop, and get yourself learning. Ask for feedback on how you come across and what message you send with your body language. Know the subtleties of touching and complimenting someone you like. Test --- yes, test! --- your skills on friends and co-workers you find attractive. The more you do it, the more confident you’ll be. And even if at first it all seems unnatural, after a few dates, you’ll find your style in no time.



6. Make sure that you’re ready for a relationship.

Very important question for you: if things work out between you and your date, are you ready to take things to the next level? Because if you’re afraid of commitment, then you might be unconsciously rejecting every suitable candidate for you just so you won’t be vulnerable. Or if you’re simply afraid of being alone, you might be approaching the whole process with some kind of desperation. Date because you’re ready to be in a relationship. If not, give it some time or get some help from a coach or therapist.



7. And lastly, have the certainty that you are a person worthy of being loved.

This is probably the best advice of all. All people have insecurities and doubt, but at your core you should know that you are deserving of the very best, and therefore will strive to look for the very best. Knowing your worthy means you don’t allow yourself to be abused, or you won’t simply take the first person that comes along.